Is Your Histamine Intolerance Actually Mast Cell Activation Syndrome?

Are you wondering if your histamine intolerance or allergic reactions are actually an issue with your mast cells? Or maybe you’ve experienced chronic symptoms that seem like allergies for as long as you can remember?

Histamine is an important but potentially dangerous mast cell mediator and part of the immune system response. Histamine is secreted by mast cells into surrounding connective tissues when there’s an exposure to an allergen. Histamine works by increasing the permeability of blood vessels and allowing white blood cells and proteins to access affected tissues more easily.

Histamine intolerance is a condition that’s growing in recognition. However, it is mostly considered a part of a much wider problem which is defined as Mast Cell Activation Syndrome (MCAS); a situation in which part of the innate immune system becomes hyperactive and releases multiple inflammatory mediators, of which histamine is one.

Histamine intolerance is considered to be present when there is just too much histamine in your body for it to cope. This is further exacerbated by the fact that histamine is also present in many foods and so a person’s histamine burden may be further amplified by their diet. This histamine isn’t broken down due to a DAO gut enzyme deficiency, or a HNMT deficiency in the liver. A comprehensive guide regarding the low-histamine diet can be found here.

Histamine intolerance is a subset of MCAS

Mast Cell Activation Syndrome is often confused for histamine intolerance. The difference between the two is that when a person has MCAS, their mast cells secrete many mediators, not just histamine. Though, histamine is still a major component of MCAS it’s only a piece of the puzzle.

Histamine intolerance is actually a subset of MCAS. If you’ve discovered you’re histamine intolerant or recently received a diagnosis, you should also be tested for MCAS.

Conditions associated with MCAS

Because MCAS is a multisystem condition with inflammation at it’s core, it’s been associated with a number of other conditions including:

  • Chronic inflammatory response syndrome (CIRS)
  • Irritable bowel syndrome
  • Gut dysbiosis – the gut is rich in mast cells and home to over 70% of the immune system. Parasites, bacteria, fungi, and parasites can all trigger gut mast cells.
  • Obesity
  • Diabetes
  • Asthma and allergies
  • Autoimmune diseases (such as lupus, rheumatoid arthritis, and Hashimoto’s)
  • Candida overgrowth
  • Celiac disease
  • Parasite infections
  • Skin conditions such as eczema and psoriasis
  • Food intolerances and allergies
  • Gastroesophageal reflux (GERD)
  • Infertility and endometriosis
  • Postural orthostatic hypotension (POTS)

If you’ve been diagnosed with one of these associated conditions, it could mean that being diagnosed with MCAS is more likely. Make an appointment with a doctor who specializes in MCAS and begin the diagnostic process. It can be somewhat of a journey, but once you know you have MCAS there’s a lot that can be done to relieve your symptoms and improve your life.

For a comprehensive guide on Mast Cell Activation Syndrome, you can read my in-depth article, Mast Cell Activation Syndrome and Histamine: When Your Immune System Runs Rampant.

Resources:

https://www.ncbi.nlm.nih.gov/pubmed/25773459

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507480/

https://www.ncbi.nlm.nih.gov/pubmed/15462834

Toxic Mold Illness: Is Your Home Causing Your Mysterious Symptoms?

If you are suffering from chronic symptoms such as asthma, fatigue, or brain fog, and you’ve struggled to find a proper diagnosis or relief, it might be time to examine your environment more closely.

Toxic mold illness and its effect on the immune system, called chronic inflammatory response syndrome (CIRS) is a perfect example of the power of our environment to impact our health in a dramatic fashion.

Many toxic molds are formed in buildings that have suffered water damage through flooding, condensation or high humidity. It is estimated that as many as 50 percent of homes have poor indoor air quality with water damage and the resultant mold biotoxins and associated inflammatory particles being one of the major contributors. With indoor air pollution accounting for up to 50 percent of all illnesses in the United States, this is a very serious contributor to patients' suffering, and deserves to be raised as a major factor when enquiring into patients' health history and timeline of symptom presentation.

Globally, air pollution is an epidemic, killing an estimated seven million people and is responsible for one in eight global deaths each year. This is a staggering number, and the fact that mold illness is one of the contributors to this epidemic, is still relatively undiscussed and unknown in traditional medical clinics, needs to change. Let’s shed some light on this invisible illness.

The Invisible Illness

Mold is quite literally an invisible killer because often you cannot see it. Caused by multiple different types of fungi, mold reproduces by forming tiny spores, which float away and are unseen by the naked eye.

Not only are mold spores invisible, but they produce even smaller secondary mycotoxins which are able to sneak through the body while wreaking havoc and remaining undetected by the immune system. These mycotoxins are extremely small, fat soluble molecules.

These molecules are particularly dangerous because they are capable of passing through your cell membranes without being carried through the bloodstream – making them extremely difficult for your immune system to identify.

Without identifying and helping your immune system recover from a buildup of toxin exposure, you could unnecessarily suffer from long term negative health consequences. Helping the public understand and become aware of CIRS is one of the best ways we can rectify unnecessary suffering.

Let’s examine the 13 symptoms of mold illness or CIRS, 4 common misconceptions, and 11 steps you can take towards effective treatment.

13 Symptoms of Toxic Mold Illness

The problem with toxic mold illness is it can feel like a phantom illness. The symptoms seem unrelated and can cause doctors to look in all the wrong places for a diagnosis.

Many sufferers of mold illness or CIRS first endure years of misdiagnosis or are even dismissed as having an illness that’s psychosomatic (in the mind). If you are suffering from a myriad of seemingly unrelated symptoms, it’s time to consider your home and work environments.

Here are the 13 most common symptoms of toxic mold illness (Dr. Shoemaker has identified 37 symptoms in total). It’s time to see your doctor if you suffer from any of the following:

  1. Cognitive issues such as headaches, brain fog, memory problems, difficulty concentrating, and mood swings
  2. General fatigue and weakness
  3. Muscle aches, joint pain, and morning stiffness
  4. Numbness and tingling of the skin
  5. Light sensitivity, blurred vision or red eyes
  6. Asthma, persistent coughing, sinus issues or shortness of breath
  7. Skin tingling or numbness
  8. Vertigo and tremors
  9. Metallic taste
  10. Temperature fluctuations or night sweats
  11. Increased urination and excessive thirst
  12. Changes in appetite
  13. Abdominal pain, nausea, diarrhea, and bloating

As you can see, the symptoms of mold illness are varied and may even appear unrelated. It’s the nature of these broad reaching symptoms that keeps the cloud of mystery over CIRS.

Only through drawing more public attention and dispelling common myths around CIRS can we get closer to achieving better diagnoses and treatments. Let’s start that process by taking a closer look at the four common misconceptions surrounding mold illness.

4 Common Misconceptions of Mold Illness

Toxic mold illness is gaining traction in the media but with that come some misconceptions. Let’s clear up some of these fallacies regarding mold illness right now.

1.  Mold Illness Isn’t That Common

Even though mold illness isn’t widely discussed, it is very prevalent and the public needs more information on CIRS. Approximately one in four have the potential for developing CIRS if they are exposed to sufficient biotoxins and inflammagens (other toxic compounds released by water-damaged buildings).

And unfortunately, these biotoxins are estimated to impact as many as half the homes in the United States, making CIRS an illness of major concern. It’s important to spread awareness of mold toxicity and prevalence so that people can take the right steps to keep their family safe in their homes and places of work.

2.  Mold Illness is Caused by Mold

Even though “mold” is in the description, mold illness is actually a complex health condition that fits more appropriately under the title of chronic inflammatory response syndrome or CIRS.

Originally described by Dr. Ritchie Shoemaker in the late 90s, there are now over 1700 scientific articles on CIRS to date.

The causes of CIRS are collectively known as biotoxins and are frequently associated with water-damaged buildings, though they can occur without water damage.

These biotoxins include:

  • Fungi with mycotoxins
  • Bacteria with secondary endotoxins (including Borrelia and Babesia - organisms associated with tick-borne illness)
  • Actinomycetes
  • Mycobacteria
  • Beta Glucans
  • Hemolysins (toxins produced by bacteria, often residing in deep nasal passages).
  • Microbial Volatile Organic Compounds (VOCs)
  • Cell wall fragments
  • Protozoa
  • Building material VOCs

Not everyone will become sick if they are exposed to sufficient levels of any of these toxins. They are fortunate to be part of the 75 percent of the population whose immune system recognizes these toxins and is able to neutralize them.

However, those with specific human leukocyte antigen (HLA) genes have an immune system that isn’t able to identify these toxins. If your body can’t identify these biotoxins, then it is unable to eliminate them from the body. These biotoxins initiate a significant inflammatory response called CIRS.

3. CIRS Looks the Same for Everyone

Actually, it appears that everyone has differing levels of mold sensitivity. Genetic predisposition seems to play a role in how likely you are to develop CIRS.

About 25 percent of the population is genetically susceptible to developing CIRS, while two percent are highly sensitive and more likely to experience disabling symptoms when exposed to biotoxins.

The varying levels of sensitivity to biotoxins makes CIRS a difficult illness to diagnose. Furthermore, those suffering from mold illness are often misdiagnosed or their condition is overlooked altogether.

Only through additional studies, examination, and public awareness can we begin to improve diagnosis rates for CIRS.

4.  Removing Environmental Exposure Cures the Symptoms

It seems obvious that the first step of tackling your CIRS would be removing exposure to biotoxins. But that isn’t always enough.

Sure, removing the source of toxins is great in theory, but even professionals have a hard time fully eliminating all the mold and spores. If it’s at all possible, a complete move from the contaminated area is best. Unfortunately, many cannot afford to completely remove themselves from the toxic environment.

Luckily, there are other steps you can take to help your body repair some of the damage caused by harmful biotoxins or improve your health if you are not able to completely remove yourself from the environment.

Take Action – 10 Treatments of Toxic Mold Illness

If you’ve been diagnosed with CIRS there are steps you can take to help alleviate your symptoms.

The steps of the Shoemaker Protocol outlines a detailed treatment plan on the impacts of toxic mold. 10 treatments I recommend include:

  1. First and foremost, remove yourself from the environment to the best of your ability. Begin the process of remediation of your water-damaged environment. It is best to consult an expert in the field who has been trained in the Shoemaker method of mold remediation.
  2. Invest in a high-quality indoor HEPA air filter capable of removing particles less than 0.1 microns. Most commonly purchased HEPA filters only filter particles to 0.3 microns and above.
  3. Test for and treat any nasal bacterial growth, such as MARCONS .
  4. Use cholestyramine, Welchol (known as Lodalis in Canada) to aid your body in removing the toxins by binding to them. Be sure to avoid constipation while using binders. Add magnesium oxide or citrate powders to prevent constipation during your detoxification process.
  5. Eliminate gluten and remove mycotoxin-rich foods, including wheat, barley, rice, oats, rye, peanuts, and brazil nuts.
  6. Eliminate amylose rich food, sugar and alcohol.
  7. Correct androgens such as DHEA and testosterone.
  8. Correct your cortisol and ACTH levels.
  9. There are several other biomarkers that can be examined and corrected with the guidance of your doctor such as ADH/osmolality, MMP9, VEGF, C3a, C4a, TGF beta-1, and VIP. Be sure to discuss these factors with your doctor.

 

It’s really a wonderful thing to finally see a comprehensive look at human health begin to hit the mainstream. And while it’s an approach you’ve been following for some time now, it’s important that it continues to spread far and wide.

Through the 7 Stages of Health and Transformation we can examine health impacts such as toxic burden through a lens that’s more complete and acknowledges the complexity of human health.

Mold illness is a perfect example of how toxins found in the 1st stage – the Extended Body – can lead to an array of seemingly confusing symptoms. If you are suffering from chronic illness – especially any of the symptoms listed above – be sure to consider mold and its resultant toxic effects, as a possible contributor.

Do your symptoms improve when you’ve been on vacation? Have you been looking for solutions to an illness with little to no success? Mold toxicity is not usually a factor many practitioners look at first. Mold illness is quite literally “out of sight, out of mind” but it could be the solution to your mysterious health woes.

As we mentioned earlier, CIRS is still a relatively unknown illness and spreading the word is vital to helping those that suffer. Share this article to help spread awareness and aid in calling attention to a debilitating and misunderstood illness.

Also, if you’re interested in digging deeper and learning more about CIRS and finding a complete description of both the diagnosis and treatment, you can find out more by clicking here.

Resources:

https://www.survivingmold.com/docs/HOFFMANESSAY1.PDF
https://www.survivingmold.com/docs/CONSENSUS_FINAL_IEP_SM_07_13_16.pdf
https://www.survivingmold.com/docs/MEDICAL_CONSENSUS_1_19_2016_INDOOR_AIR_KB_FINAL.pdf
https://www.truthaboutmold.info/statistics
https://irp-cdn.multiscreensite.com/c4e267ab/files/uploaded/AEDOWicfSFCZ5IZG5OhO_WHO_ 7%20million%20premature%20deaths%20annually%20linked%20to%20air%20pollution_March%202014.pdf
http://www.survivingmold.com/mold-symptoms/molds-mycotoxins-more
http://www.survivingmold.com/docs/Berndtson_essay_2_CIRS.pdf
https://hoffmancentre.com/wp-content/uploads/2016/12/Steps-of-the-Shoemaker-Protocol. pdf

Dr. Bruce Hoffman is our Newest Certified Physician! | Press Release from Surviving Mold

Press Release From Surviving Mold:

Dr. Hoffman is a family physician and director of the Hoffman Centre for Integrative Medicine in Calgary, Alberta. He was born and educated in South Africa, obtaining his medical degree from the University of Cape Town. He emigrated to Canada in 1986 and pursued family practice in rural Saskatchewan. Dr. Hoffman has been practicing in Calgary for the past 25 years. Dr. Hoffman is a certified Functional Medicine practitioner (IFM), has obtained his Master's Degree in Nutrition (University of South Florida) and is board-certified in Anti-Aging and Regenerative Medicine (A4M). He has also completed additional training in the treatment of Lyme disease and other tick borne co-infections (ILADS). In addition, he is the medical director of the Brain Treatment Centre of Alberta, utilizing QEEG and neuro/biofeedback to treat brain disorders.

Dr. Hoffman first heard Dr. Shoemaker lecture in 2001 and has remained an observant student of Dr. Shoemaker’s (and allied health researchers and clinicians’) ground-breaking discoveries ever since. In 2010, Dr. Hoffman began to implement the CIRS protocols in his practice and was able to obtain, in Canada, the lab tests, and medications required for the effective implementation of these protocols. He is, at present, the only Canadian medical doctor trained and qualified in the CIRS approach to treating chronic illness. When the housing market boomed in Calgary in 2007, many homes were constructed at a rapid pace. The city building inspectors performed perfunctory home inspections, and many homes were built with less-than-adequate roof ventilation. His newly constructed duplex in Calgary was not exempt; in 2014, he noticed dark stains around the pot lights, leaking intake vents, water stains in the basement and more. Having mold in his own home was an incredible learning experience but also an awful way to gain such experience.

Dr. Hoffman is deeply grateful for the guidelines provided by Dr. Shoemaker’s team emails and the consensus statements they have written (essential reading - available on www.survivingmold.com). Calgary experienced a dramatic flood a few years ago, during which half the city and the surrounding areas were underwater for several days. Since that time, many patients have been screened for CIRS, with a large number meeting the criteria for diagnosis. With Canada having a provincially funded health care system, it was an interesting experience having to work outside the local health care system to obtain US-based labs and treatments. Dr. Hoffman has laid all the groundwork for reproducing the CIRS work up in Canada. There is, however, only a single center in all of Canada willing to perform Neuroquant MRIs (private only, paid for by the patient). Finally, as of July 2017, Canada has an available source of VIP!

From: Surviving Mold - You can read the full article here