Natural Treatments for Mast Cell Activation Syndrome

I have recently returned from a most stimulating conference/think tank with Dr. Afrin and 30 other leading clinicians on Mast Cell Activation Syndrome (MCAS) at Commonweal—a cancer retreat centre in northern California.

MCAS is a type of mast cell activation disorder (MCAD) characterised by an abnormal activation of mast cells resulting in chronic multisystem polymorbidity of a general inflammatory nature, with or without an allergic nature. Mast cells are white blood cells that are concentrated at the entrances to body tissues (ears, ears, nose throat, skin, genitalia, rectum), and when activated, they release over 200 signalling chemicals (e.g. histamine, prostaglandins, leukotrienes, cytokines and chemokines). These chemical mediators trigger inflammation in response to the invasion of foreign toxins, infections or chemicals, resulting in a range of chronic symptoms. With MCAS, this function becomes upregulated and chronic, occurring at inappropriate times in response to substances that are not necessary a threat. This can lead to widespread symptoms in many different body organs and systems.

Mast cells are located throughout your body in many different tissues, primarily including dermatological, gastrointestinal, neurological and respiratory tissues.  While we need mast cells to protect us from threats, they become a problem when they are overactive and hyper-responsive and will not ‘turn off’. Dr. Afrin, a leading mast cell researcher, believes that between 15 and 20% of the North American population may be affected  by MCAS. The symptoms of MCAS vary greatly. As a result, many people spend years, even decades, in search of a correct diagnosis, visiting many different subspecialists. What is more frustrating for patients is that many doctors are not familiar with the multiple ways in which MCAS may manifest.

MCAS is often found in individuals with hypermobility syndromes (Ehlers–Danlos syndrome), postural orthostatic hypotension (POTS) as well as chronic inflammatory response syndrome (CIRS) and tick-borne illnesses (Lyme disease and co-infections).

The most common symptoms of MCAS include:

  1. Feeling as though you have been sick forever
  2. Trouble with allergies and asthma
  3. Overreaction to insect bites, bee stings and chemical intolerances
  4. Facial and chest flushing
  5. Skin rashes that come and go, including hives and angioedema
  6. Itchiness and a burning feeling
  7. Brain fog and headaches
  8. Poor wound healing and easy bruising
  9. Waxing and waning of symptoms

The condition may be mild in some people and only exacerbate in response to a significant life stressor, which may be either physical or psychological in nature (divorce, bankruptcy, loss of job, travel, infection, death of a loved one, exposure to novel infections, occupying a water damaged building, exposure to cold or heat). In others, symptoms may develop from a young age and slowly become worse over time. People with MCAS are likely to experience a few of the most common symptoms. Because mast cells are located throughout the body, symptoms can affect the eyes, nose, ears, throat, skin, heart, blood, lungs, gastrointestinal tract and the nervous, endocrine and musculoskeletal systems.

The symptoms of MCAS are often confusing. For a long time, many people with MCAS have been told that their condition was psychosomatic or ‘in their head’. Fortunately, awareness of this frustrating and debilitating condition is spreading. Testing for MCAS is somewhat complex and confusing, as positive biomarkers may only be observed when a patient has a flare up. Incorrect collection of specimens may also lead to false negative testing. Many specimens need to be chilled with a refrigerated centrifuge, which is not available in every lab or doctors’ office.

If you need a comprehensive overview MCAS, I encourage you to read my article: Mast Cell Activation Syndrome and Histamine: When Your Immune System Runs Rampant.

The most common drugs that are prescribed for treating MCAS include:

  • Histamine 1 blockers – Hydroxyzine (Atarax), Doxepin (Silenor), Cyproheptadine (Periactin), Loratadine (Claritin), Fexofenadine (Allegra), Diphenhydramine (Benadryl), Ketotifen (Zaditen) and Cetirizine (Zyrtec, Reactine).
  • Histamine 2 blockers – Famotidine (Pepcid, Pepcid AC), Cimetidine (Tagamet, Tagamet HB) and Ranitidine (Zantac). Famotidine is chosen most often because it has fewer drug interactions than Tagamet.
  • Mast Cell Stabilisers – Cromolyn (Cromolyn Sodium, Gastrocom—oral form, Nasalcrom—nasal spray, Opticrom—eye drops, and there is a nebulised form and a cream can be made from a bottle of Nasalcrom and Eucerin or DMSO cream), Ketotifen (both a mast cell stabiliser and an H1 blocker) and Hydroxyurea (Hydrea).
  • Mast Cell Inhibitors – Montelukast (Singulair), Zafirlukast (Accolate) and Zileuton (Zyflo). Pentosan (Elmiron) is used in the genitourinary tract for perineal pain and interstitial cystitis.
  • Antibody neutralisers – Omalizumab (Xolair).
  • Tyrosine Kinase Inhibitor – Imatinib (Gleevac).
  • Stimulants – Mixed salts amphetamine (Adderall XR), Methylphenidate (Ritalin) and Ephedrine (Epipen provides an acute rescue injection when experiencing an anaphylactic episode).
  • Non-steroidal anti-inflammatory (NSAIDS) – Helpful in some, a trigger in others.  Aspirin is the most commonly used NSAID. COX 2 selective NSAIDs—Celecoxib (Celebrex)—are also used.
  • Low-dose Naltrexone (LDN) – Used in a step-up dosing at night.
  • Cannabinoids – Drobaninol downregulates neurons and mast cells via inhibitory cell-surface cannabinoid receptors (not available in Canada). CBD is more helpful than THC.
  • Benzodiazepenes – Addresses the inhibitory mast cell benzodiazepine receptors. Use short-acting varieties. Lorazepam (Ativan) and Clonazepam (Klonopin, Rivotril) are best when used three times daily. Valium and Midazolam are also sometimes used.
  • Selective Serotonin Reuptake Inhibitors – may occasionally be of benefit.
  • IV Immune Globulin (IVIG) – this treatment is sometimes used in MCAS.

While your doctor may prescribe you some of these mast cell stabilizer drugs to help your symptoms, there are also several natural treatment options. A benefit of using natural treatments for MCAS is that you can take these on your own and they do not require a prescription. However, because most patients with MCAS present differently, it is a good idea to implement these with the guidance of a functional medical doctor who is experienced in MCAS.

Although there is a good possibility that you will eventually find the right therapeutic combination of treatments that will help alleviate many of your symptoms, the fact is that there are no specific biomarkers that will predict which therapy will be the most effective for your specific manifestation of this condition. Trial and error with both drug- and non-drug-based options is often the name of the game.

Also, if you opt for natural treatments for MCAS and mast cell activation disorder, always be sure to disclose everything you are taking to your doctor so he or she has a clear idea of what is going on. It is also important that you make only one change at a time when attempting different combinations of treatment options.

Advantages of Using Natural Treatments for Mast Cell Activation Syndrome

There are many advantages of using natural treatments for MCAS, including:

  1. Lower cost
  2. No need for a prescription
  3. MCAS patients are often sensitive to pharmaceuticals, particularly the excipients (bulking agents, binders, fillers, dyes) within the products. Patients will have to work closely with their compounding pharmacists to help identify a list of offending ingredients in drug formulations. If a patient has a strange reaction to medications (e.g. insomnia while using a typically sedating antihistamine), it is likely a flare up of mast cells in the CNS causing the problem and not the drug itself.
  4. Some drugs block DAO—an enzyme in the gut that breaks down histamine
  5. Many patients prefer natural treatments
  6. May have benefits beyond mast cell stabilisation

Disadvantages of Using Natural Treatments for Mast Cell Activation Syndrome

  1. Supplements are bioactive compounds that may have unacceptable effects
  2. They may interfere with known medications
  3. They still have to be processed through the same liver detoxification enzymes as pharmaceuticals and thus may have unacceptable side effects
  4. Supplements may also contain excipients that produce unacceptable side effects

Many of my patients find that these natural treatments are sufficient when it comes to treating their MCAS. For others, these natural treatments allow them to reduce the number or amount of drugs they need. When it comes to natural treatments for MCAS and mast cell activation disorder, the most effective work in the following ways:

  1. Stabilising mast cells
  2. Increasing histamine breakdown
  3. Reducing histamine levels
  4. Stabilising the immune system and reducing inflammation

With that in mind, here are some of the best natural treatments for MCAS according to the mechanisms they influence. These recommendations were presented at the think tank by Dr. Brian Bouch, a leading integrative medical doctor from California.

1. Stabilising Mast Cells

One of the best things you can do for MCAS is add natural treatments that stabilise your mast cells. Such therapies work by inhibiting the inflammatory mediators mast cells release and can be broken down into three groups (A, B, and C) based on how helpful and potent they are.

The “A” Team:

  1. Quercetin  – 2000 mg daily, dose divided
  2. Green tea (EGCG, L-Theanine) – 2 to 3 cups daily. Supplement with 500 mg (175 mg of ECGC) twice daily
  3. Curcumin (Meriva is a common brand name) – 1 to 4 g daily, dose divided
  4. Chamomile tea (Apigenin, luteolin) – 1 to 2 cups before bed
  5. Resveratrol – 20 mg twice daily
  6. Diamine oxidase enzymes (DAO) – 2 capsules with each meal
  7. Vitamin C – may need a non-citrus source such as rose hips – 1 to 3 g daily

The “B” Team:

  1. Luteolin – 100 mg twice daily
  2. Ginkgo biloba – 500 mg daily
  3. Silymarin – 500-1000 mg daily, doses divided
  4. Shea oil – 3 capsules daily
  5. Ellagic acid – 500 mg daily
  6. Pycnogenol – 500 to 1000 mg daily
  7. Magnolia/Honokiol – 200 to 250 mg twice daily
  8. Parthenolide (Feverfew) – 200 to 400 mg twice daily

The “C” Team:

  1. Fiestin – 100 mg twice daily
  2. Rutin – 200 mg daily
  3. Genistein (isoflavone)
  4. Mangostin (often taken as a juice) – 500 to 1000 mg daily
  5. Xanthium (dihydroleucodeine, also known as cocklebur) – 6 to 9 capsules daily
  6. Isatis (indoline) – 6 to 9 capsules daily

Here is some further information about select products that are used most often


  • Found naturally in stinging nettle, grapefruits, onions, apples, black tea, leafy green vegetables and beans
  • Downregulates the enzyme that converts the protein histidine to histamine—histidine decarboxylase
  • Inhibits the release of histamine, prostaglandins and leukotrienes— three of the most common inflammatory mediators found in MCAS
  • Decreases the production and release of inflammatory cytokines—the inflammatory mediators responsible for many of the symptoms of inflammation related to MCAS
  • Often used as a primary therapy—has been shown to be more effective than the pharmaceutical Cromolyn
  • Treats allergies, contact dermatitis, photosensitivity and inflammation
  • The dihydrate form has the best bioavailability
  • Dr. Theoharides, a top mast cell researcher, has produced a product called NeuroProtek, which contains quercetin, luteolin and rutin. At least 8 capsules must be taken daily for maximum effect.

Green Tea – EGCG

  • EGCG is the most common polyphenol found in green tea
  • Inhibits calcium influx into mast cells, thus preventing their degranulation
  • Inhibits mast cell production of inflammatory mediator leukotriene C4.
  • Has other benefits: improves brain function, improves dental health, lowers risk for cardiovascular disease, combats skin aging
  • Lowers risk for Alzheimer’s disease, Parkinson’s disease and diabetes mellitus


  • Widely used in popular supplements for lowering inflammation
  • Best found in phospholipid forms such as Meriva
  • Has antiallergic activity—inhibits the degranulation of mast cells in a dose-dependent manner
  • Inhibits inflammatory molecules—interleukin-4 and tumour necrosis factor -?
  • Widely used in cancer and joint inflammation


  • Found in grapes, berries and peanuts
  • Reduces the expression of inflammatory markers IL-6 and IL-8
  • Inhibits IgE allergy reactions

Vitamin C

  • Research has shown that when Vitamin C levels fall in the blood, histamine levels increase exponentially. When Vitamin C is reintroduced, histamine levels fall exponentially
  • There is very little evidence in the literature, however, to support its use as a natural antihistamine
  • It is frequently combined with quercetin in supplements—a popular supplement is Natural D-Hist by Ortho Molecular Products. Take 2 three times per day for maximum effect
  • Be careful of citrus-based Vitamin C and be aware that high does can cause diarrhoea. It is best to take smaller amounts more frequently
  • Slow-release formulations may be better


  • Silymarin, an extract of milk thistle, which has been shown to attenuate mast cell-mediated anaphylaxis-like reactions
  • It also prevents the release of proinflammatory cytokines such as tumour necrosis factor, interleukin 6 and nuclear factor–kappa B.
  • Also known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. Widely used to protect against drug- and chemo-induced liver toxicity

Other supplements that have been used in MCAS:

  • Lipoic acid
  • N-acetylcysteine
  • Ashwagandha – an Ayurvedic remedy known as an adaptogenic herb that modulates the body’s response to stress. Withaferin A is a compound found in ashwagandha that has been shown to prevent mast cells from releasing histamine and other inflammatory mediators
  • Vitamin D – usually best at higher doses. Need to test blood levels

Important Caveat:

Both quercetin and green tea extracts may inhibit the COMT enzyme. If you have a COMT ++ enzyme (slow function) on your 23andme, be careful when using these two supplements. The COMT gene determines your ability to process catechols, oestrogen and the major neurotransmitters adrenaline, noradrenaline and dopamine. Your anxiety, insomnia and pain may increase due to further slowing down of the excretion of these excitatory chemicals plus the excitatory catechols, substances found in green and black tea, coffee, chocolate, green coffee-bean extracts and quercetin.

Other things to consider in MCAS patients:

  1. Ensure you have sufficient magnesium levels, as a deficiency has been shown to induce the emergence of mast cells, particularly in the liver. Magnesium also has hundreds of other important functions in a healthy body.
  2. Zinc is another mineral you should ensure you’re getting enough of because it is important in appropriate mast cell signalling.
  3. Stress reduction is also important in stabilising mast cells. When you’re stressed, your body releases corticotropin-releasing hormone (CRH), which is associated with the activation of skin mast cells. Incorporate meditation, yoga, breathing exercises and other stress-reducing techniques into your daily life.
  4. Maintaining a schedule is a great way to help stabilise your mast cells because they exhibit circadian rhythm patterns. Try to wake up and go to sleep at the same time each day. Also, avoid electronic screens before bed or wear a pair of blue-blocking glasses for better hormone regulation.

2. Increasing Histamine Breakdown

Diamine oxidase (DAO) stabilises mast cells, but more importantly, it is the predominant enzyme that breaks down histamine. To increase your DAO levels, you can take DAO enzymes. I recommend taking two capsules with each meal. You can also increase your DAO levels with high doses of vitamin C.

You should also avoid anything that blocks the release of DAO. First and foremost, this includes any form of alcohol. Histamine and alcohol metabolic pathways share common enzymes—aldehyde oxidase and aldehyde dehydrogenase. When you drink alcohol, histamine is released from your mast cells and DAO is simultaneously inhibited. This can cause a runaway chain reaction, which results in greater sensitivity to alcohol and worsening histamine intolerance. Aged cheese and wine together may induce a major mast cell activation.

3. Reducing Histamine Levels

To reduce histamine levels in your body, you should adopt a low histamine diet. Avoid the following:

  • Alcohol
  • Smoked and cured meat
  • Seafood
  • Pickled foods
  • Fermented foods
  • Leftovers
  • Canned fish or meat
  • Berries, especially strawberries
  • Nightshades, including tomatoes and potatoes
  • Preservatives
  • Vinegar

Try to eat foods as fresh as possible, and stick to anti-inflammatory foods. Adding rosemary oil to fish reduces histamine formation as the fish ages.

For a comprehensive resource on low-histamine foods, diets and recipes, I recommend my guide on the Low Histamine Diet as well as Healing Histamine.

4. Stabilising the Immune System and Reducing Inflammation

Calming the immune system and reducing inflammation is a critical part of any MCAS protocol. The recommendations above mainly help to stabilise the immune system and reduce inflammation, though there are a few other effective methods:

  1. Check and treat any underlying infections – These can contribute to a widespread inflammatory response in the body if left untreated. These may include H. pylori, Epstein Barr and herpes simplex.
  2. Correct gut dysbiosis – Correcting the balance of your gut microbiome has been shown to reduce inflammation and improve immune system health. Specifically, there are certain strains of probiotics that have been shown to help breakdown histamine, including:

Many patients will need to experiment with various therapeutic options at different doses until they find the right combination of medications that helps with their particular symptoms. If unusual side effects are experienced with known medications, remember that the excipients contained within the medications may be the problem, not the medications themselves.

While there is no cure for MCAS, there is a lot you can do to minimise the condition’s impact on your life. The good news is that most of the natural treatments for MCAS are recommendations for a healthier life that anyone would benefit from. To read more about living with MCAS, check out 12 Tips for Living With Mast Cell Activation Syndrome.

With a chronic illness such as MCAS, it is possible to live a full life—the treatment just requires a careful, comprehensive approach. If you believe you have MCAS or have already received a diagnosis and need a functional medical doctor who specialises in MCAS in Calgary, Alberta, you can request an appointment here or call 403-206-2333.

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48 thoughts on “Natural Treatments for Mast Cell Activation Syndrome”

  1. Thank you for this very generous and helpful information.
    Do you think that tincures in alcohol (Herb Pharm) present a problem? Even if it’s not ideal, is it still usable? I have a lot.

    I was scripted Cromyln Sodium (in vials). I haven’t used it as the potential side effects have effectively scared me off.
    Your thoughts?

    • Alcohol may be tolerated by many but some people are quite sensitive to it and prefer glycerin based herbal tinctures. One can “burn off” the alcohol in tinctures by placing the remedy in a small amount of water that has just been brought to the boil and is cooling off.

      Cromolyn is a fantastic remedy for many with MCAS and food reactions. Be sure to eat a low histaminic diet if MCAS is a problem

      • So grateful for you concise overview. Especially for your generosity sharing it. My daughter has salicylate sensitivity so low histamine foods are often triggers for low sals. Just wondering if you have any ideas. I dont expect you do but in case. ???? My son is not low sals so it is wonderful to have this clear breakdown as he has finished Uni its time to make best choices for himself.

    • Thank you million times over for this information, could you tell me what to eat more in mastocytosis to reduce histamine

    • Thank you for joining us all the way from Brazil and reading our article. I hope that you found the information useful.

  2. Thank you a million times over for this information, I keep in close to me when I’m getting discouraged looking for a doctor in CA who understands MCAS. I wish I had the funds to fly to Canada!

    • Thank you very much! I hope you will find someone who will help you better understand MCAS with you, but we are always available to you here if you ever need.

    • Hi Laura, I don’t know where you are in California, but I live in California and am MCAS positive. The doctor I see who is also the doctor who diagnosed me after many doctors said my symptoms were in my head is Dr. Xi at USC Keck School of Medicine and she is an allergist. She is patient, understanding and very detail oriented. I hope this helps.
      Take care, Jeri Allen-French

  3. Dear Mr. Hoffmann,

    many thanks for these precious informations and for sharing with us your huge holistic knowledge. Also that you include the gene problem is great. Such doctors like you are currently still rare in Germany.
    Many greetings from Germany

    • Thank you Carola! I hope that more doctors will be able to share this kind of knowledge all around the world so that we may all be able to better serve people of all backgrounds.

  4. Trying to look at my onset Tinnitus after a summer 2019 allergic response, had wheezing in my right lung for a couple weeks.. medical history includes cisplatin 5+ years ago.. so I have a high pitched eeeee that just came about triggered by what i believe was this allergic response.. Now in 2020 i notice some of the same symptoms entering the July period.

    Right now Im trying N-Acy Glucosamine (NAG) Longvida Curcumin (Crosses BBB) , Melatonin 1mg before bed and L-Thenaine.

    I am completely onboard with doing something about gut health and diet regarding inflammation and mast cell.

    The Silymarin is interesting. As is the Vitamin C and some others all cross over.

    • When we consider making changes simply with gut health and diet, it can be the stepping stone in the right direction to a long term solution. I hope this information helps get you started!

  5. Thank you so much for this extremely helpful resource. I came into this whole MCAS business with a big bang last year after a wasp sting. I was basically a case for care takers vor 3 months, one of which I spent in hospital after being brought to the ER 3 times in one week. It’s been a scary time and I am thankful for a fantastic doctor who eventually helped by putting me on an exclusion diet (1 week of potatoes and rice only and building up food items every 2-3 days), H1 and H2 anti-histamines and finally after a few weeks debate – Xolair. However, I am constantly learning and educating myself on “natural support”, hoping to be able to find my balance and reduce medication over the years. Your information contains quite a number of things I have – despite excessive research – not come across yet. I would like to thank you for your afforts and appreciate any updates on the matter. Liebe Grüße

    • Thank you for your comment! It is always hard to find information when you’re explicitly seeking it, but when you come across something new a solution always feels so much closer!

    • I have been diagnosed with systemic mastocytosis my doctors want me to go on Xolair but I am afraid it will put me into anaphylaxis . Can you tell me how long you have been on the Xolair and have you had positive results?

      • Unfortunately, we are not able to answer this question. We are only able to answer medical questions if you are a patient and we have a medical history and are working with Dr. Hoffman as a patient.

    • Thank you Brittany for taking the time to read the article, we hope you may consider sharing it among your friends and family so they may also find it useful!

  6. This article was very eye opening. My son was diagnosed with MCAS and has suffered most of his young life. He has been taking Cromolyn for several years now. Recently, he has given up soccer due to the discomfort the amount of running causes him ( nausea and fatigue) and has seemed to develop some anxiety and insomnia. We are in search of a MAST cell expert in the Virginia, Maryland, DC area. Hard sometimes for MCAS patients to have a medical team to understand, support, and help find solutions. We are still hopeful. Thank you again for this valuable information. We learned more in this article than any information we have received over the years.

    • We are glad that you were able to find new and useful information from our post. I hope it is the first step to finding the answers you need, and to find the specialist in your area to help you first hand.

  7. Thank you very much for your generous contribution to those of us who suffer with this difficult, mysterious and widely-misunderstood illness. I have learned, as well, that Intestinal Permeability (leaky gut) pays a significant, if not sole, part in my condition. Glyphosate (RoundUp, patented as an antibiotic, and all other antibiotics) destroys the Tight Junctions in the Epithelial Lining which exposes my body (& immune system!) to everything ingested, causing my mast cells to degranulate, not the result of eating high-histamine foods. Everyone is different and your article has helped immensely. I will incorporate this into my protocols. A plant based, non-dairy, gluten-free, non-processed diet has been paramount. Now, it is only emotional, thermal or physical stress that triggers me.

    • Glad the article helped you out! With every case being unique, it’s best to take whatever information you can get and use what works for you. The more you can narrow it down, the more you can pay attention to living the life you desire.

    • Hi Marilyn,
      Thank you for your interest in our diet guide. You should have been sent an email with a link to the guide when you signed up. Please check your spam folder and let us know if you have not yet received it.

  8. Thank you for some positive information, my brother has been diagnosed recently and the little Information you find out there is so bleak and scary. This has given me hope and I will share it with my bro????????
    Always looking for a more holistic approach✨
    P.S. Would love to see the low histamine diet? How would I get my hands on that?

    • I would recommend you take a peek at another one of our blog posts, as it offers helpful information on living with MCAS, as well as offering a link to our low histamine diet guide. You can see the blog post here.

  9. Hello: Thanks for posting this. I can only describe the attacks in my nose and sinuses as some sort of attack after I drink dairy, or eat salt, or eat wheat along with some other foods. I can breathe fine but the swelling in my sinuses and the pressure in my head, upper pallet and teeth is very painful including a headache and back of the neck ache during the attack. It subsides gradually but always come back another day. It is getting more often now too. I have had hayfever as a child. My dna test tells me I have a dao deficiency as well. I want to try your natural remedies. Thanks again.

    • Thank you for sharing and commenting on our post, I hope that natural remedies are a step towards the answers you’re looking for.

  10. I am guessing that this on this page is actually an ERROR???

    “The “C” Team:”
    5. Xanthium (dihydrocodeine) – 6 to 9 capsules daily…

    Dihydrocodeine??? 6 to 9 capsules daily
    I am guessing this is NOT actually the active ingredient in Xanthium…

  11. Don’t peanuts have high histamine levels and green tea lowers the natural DAO in your body along with cummin and tumeric? Just curious, can some people tolerate these with cromyln are they ok regardless? I am having a hard time adding food to my grocery list and I hard these things were not good to add in. I guess that brings me to my next question, if you are closely following a low histamine diet, can you cheat a little with DAO suppliments or cromyln sodium.

    • Thank you for your inquiry. Without testing it is very difficult to determine your diet. Please contact the clinic at 403-206-2333 if you would like to book an appointment.

  12. Pycnogenol DOSE 500mg to 1000mg?? I been using pycnogenol for 25 years and had a histamine issue that was corrected using 200 to 230mg daily. I have never heard of dose levels of 500 and higher for pycnogenol?


  13. Does your clinic offer any financial aid options for low or no income patients? Am desperate to find an MCAS aware FM doctor but have been bounced through the system with no success so far. I have been disabled by this condition and have not been able to work for years now- I need help but the reports I hear back from other patients of your clinic clearly indicate that care there is out of reach for me fiscally. I am in BC currently, but would find a way to travel- I just can’t afford to pay 5 figures in tests alone. Is there any other option? Are there recommendations that could be made for those of us poor of health and also poor of pocket? Thank you for your time.

  14. Does anyone know of a MCAS/Histamine Intolerance specialist in the United States? I am willing to travel, even fly if I can find someone legit. So many bloggers online offer their course to help and charge hundreds of dollars. I don’t know who is out for money and who can truly help those of us with MCAS. I’m assuming Dr Afrin is the real deal and can help? I live in SC. Again, I am willing to travel but cannot afford to waste money on quacks.

  15. Thankyou so much for this
    Comprehensive information about mast cell disorder. I have been recently diagnosed along with my sister and possibly daughter secondary to Ehlers Danlos syndrome.

  16. Has anyone come up with a list of Mast Cell Activation Disease Specialists in Functional Medicine for the United States yet in a Directory Form?

  17. Thank you for the information. Recenty discovered this is what is happening to me post multiple major surgeries over the past two years and I educated my nurse practitioner today with my theory and evidence. Hopefully she will investigate further to help me and establish a practice that recognizes this diagnosis in our area.


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